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Tour de Catalogne de la 5e étape

L'Espagnol Alejandro Valverde a pris le contrôle de l'épreuve en remportant la 5e étape, sa deuxième fois de sa carrière, rendant son succès sur l'épreuve incontestable. Grâce à ce nouveau succès, Valverde s'empare du vetement cyclisme de leader au général.
Alejandro Valverde, à 36 ans bien tassés, est toujours aussi impressionnant. Il a devancé de 13 secondes le Britannique Chris Froome (Team Sky) et Alberto Contador (Trek–Segafredo). Le coureur de Movistar Valverde a célébré le 5e Tour de Catalogne(entre Valls et le sommet de Lo Port) de sa carrière, où il avait endossé le maillot Movistar Team blanc de leader.
Valverde a confirmé son triomphe en terminant premier de la septième étape de 139 km, synchronisant parfaitement son sprint sur la dernière étape, à Barcelone. Grâce à cette victoire, Valverde détrône Tejay Van Garderen (BMC Racing Team) au classement général.

NFL Playoffs 2016: Which Contender’s Week 10 Loss was Worst?

There’s little room at the top of the NFL this season and many playoff contenders lost in Week 10. Whose defeat was the worst among legitimate contenders?

Of the contenders for the NFL Playoffs in each conference, five teams with high hopes fell in Week 10. Most were very close contests, decided by only a few points on the final play. Yet all altered the playoff picture and one wholesale jerseys defeat was worst of all.

RELATED STORY: Picks, Predictions for Each Week 11 Game
Did the New England cheap jerseys Patriots suffer the worst defeat? How about the Pittsburgh Steelers or Atlanta Falcons? The Green Bay Packers and Minnesota Vikings both continued to slide as well. Not all will be making the NFL Playoffs in 2016.

Two brothers from New York, Dan Salem and Todd cheap nfl jerseys Salem discuss the NFL Playoffs race in today’s NFL Sports Debate.

Todd Salem:

Among legitimate contenders, a distinction that is obviously up for debate, whose Week 10 loss is the biggest deal?

The New England Patriots fell at home to the Seattle Seahawks
The Atlanta Falcons lost on the road to the Philadelphia Eagles
The Pittsburgh Steelers lost at home to the Dallas Cowboys
The Green Bay Packers lost on the road to the Tennessee Titans
The Minnesota Vikings lost on the road to the Washington Redskins
This is a tricky NFL season because these teams are all definitive playoff contenders. But outside of New England, none of them have elite records. Atlanta is head and shoulders above the other NFC teams and they are only 6-4. It’s been a weird year.

The Atlanta Falcons loss is actually the one that worries me the most. This ruling depends on your opinion of the contenders in question. I am eliminating Green Bay and Minnesota because I no longer believe in their ability to contend for anything. The losses hurt, but they can’t be a big deal because they are hardly surprising at this point.

The final point goes for Pittsburgh as well. It was no surprise the Steelers lost to arguably the best team in the NFL, and they played them even, right to the final whistle. That leaves either New England or Atlanta as the answer.

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The Patriots had some wiggle room, though. With a two-game lead in the AFC East, even after the loss, and a question of whether there is a single other good team in the AFC outside of the West, New England is fine. It also obviously had a good chance to win the game against Seattle. The Falcons, meanwhile, were pretty easily handled by the cratering Eagles. This is alarming.

Philadelphia ran all over Atlanta and also shut down Matt Ryan and company. Best offense in the league be damned. With Atlanta entering their bye and two tough games to follow, it’s not quite as easy to feel good about a one-game lead in the loss column over the rest of the NFC South.

Dan Salem: cheap jerseys from china

This is an excellent question which nearly included several more potential playoff teams. The Denver Broncos almost made this list, as did the Kansas City Chiefs. Dallas would be here as well, if not for Pittsburgh stealing their spot. There is no room for error in terms of winning a Wild Card spot in either conference, meaning the worst loss of Week 10 belongs to the Pittsburgh Steelers.

Pittsburgh lost its fourth straight game and finds itself looking way up at the surging Baltimore Ravens in the AFC North division. With five losses already in the books, this past weekend’s defeat to the Cowboys may have been the death blow to Pittsburgh’s Wild Card hopes. The team gets to play Cleveland twice, but every other game on their schedule is a tough one against potent offenses. The Steelers can still fight to win their division, but they’ve now dug themselves a hole that few teams ever climb out of.

This playoff hole is the reason Pittsburgh had the worst loss. Both Green Bay and Minnesota are one week away from leading the NFC North division. Their losing streaks are troubling, but the Lions do not scare me. Either team can still win that division, so their losses were not crippling. Whether they should be considered legitimate contenders is another story, but each has a solid chance at reaching the NFL Playoffs.

You nailed the New England loss perfectly. They are far and away better than the entire AFC. Seattle seems to play up or down to its competition, but now seem like a legitimately good football team. The Patriots will win the AFC East and are still in the lead for homefield advantage as well. Another loss would hurt a lot more than this one did.

NFL POWER RANKINGS: Cowboys the New No. 1 in Week 11
As for the Atlanta Falcons, it was certainly troubling to see them lose to Philadelphia. Yet the Eagles have done this twice before this season, shutting down both the Steelers and Vikings offenses. Philadelphia only has one loss outside its division and is undefeated at home. I’m not saying that Atlanta deserves a pass, but they’re still the best team in the NFC South by a long shot. Their point differential tells the real story, a whopping +37 points through 10 cheap jerseys china weeks. The next two games may pose trouble for the Falcons, but their final four all look like victories.

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NFL Week 11: Survivor Pool Stone Cold Locks

If you somehow survived the carnage of NFL Week 10, here are a slew of wholesale jerseys china stone cold locks for your NFL Survivor Pool in Week 11.

In Week 10, my record was 2-2. It’s the first time all season two of my picks didn’t pan out. The Baltimore Ravens blew out the Cleveland Browns and the Arizona Cardinals just slipped past the San Francisco 49ers. But the San Diego Chargers lost to the Miami Dolphins due to two late-game interceptions and the cheap jerseys from china New England Patriots couldn’t cash in against the Seattle Seahawks. Now, both Miami and Seattle are trending upward.

In Week 11, there are 14 games on the schedule. Unlike the previous week in which the majority wholesale jerseys of matchups had slim point spreads (and 10 of 14 games had outcomes of a touchdown or less), there are seven contests with spreads of six or more. So, there’s no shortage of picks you could roll with to survive.

MUST READ: 5 Coaches on the Hot Seat in Week 11
To be honest, all of the big spreads are appetizing. There’s not one I’d avoid. You’d think with so many lopsided lines coming out of Las Vegas, there would be at least a couple upset specials or cheap nfl jerseys trap games that set off some alarms.

I know cheap jerseys you’ve only got one shot each week, so let’s dig into the options to see if we can weed out the weaker selections and whittle down the one winner to hang your hat on.

NEXT: Stop cheap jerseys china Believin'

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NFL Inactives Week 11: Justin Houston Active, Tyrann Mathieu Out

Taking a look at the NFL inactives for each team on Sunday in Week 11, including one superstar returning and wholesale jerseys one missing another week.

Time and again through the 2016 NFL season we’ve seen some big names on the NFL inactives report each week. It’s a struggle both as fans and for the teams. Fans want to see the best players on the field and teams surely want those guys on the field. However, football is a violent sport and injuries are the name of the game. Thus, we once again venture to look at the injury reports for Week 11 and see who’s in and who’s out for each team. cheap jerseys

RELATED STORY: Picks ATS For Each Week 11 Game
Before the official NFL inactives even trickled down on Sunday morning, we got some big news about two players fans and their respective teams have been keeping an eye on. The first is Kansas City Chiefs edge-rusher Justin Houston. Houston has yet to play in a game this season after suffering a brutal knee injury in 2015 and having a long recovery. According to ESPN’s Adam Schefter, though, he’s set to make his debut on Sunday against the Tampa Bay Buccaneers.

On the more negative side of things, the Arizona Cardinals look like they’ll be without star safety Tyrann Mathieu for another week, also per Schefter. The Honey Badger spent the early part of the year getting his legs back while returning from a torn ACL in 2015. However, he hurt his shoulder right as he seemed like he may turn a corner. The middling Cards now have to wait another week to get their star back.

Here’s a look at the rest of the NFL inactives for Week 11:

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Cleveland Browns ✔ @Browns
Our inactives for #PITvsCLE:
12:30 AM — 21 Nov 2016
32 32 Retweets 42 42 likes
Baltimore Ravens ✔ @Ravens
INACTIVES vs. Dallas:
Jimmy Smith
Asa Jackson
Lorenzo Taliaferro
Elvis Dumervil
Ryan Jensen
Alex Lewis
Crockett Gillmore
12:30 AM — 21 Nov 2016
192 192 Retweets 202 202 likes
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View image on Twitter
Minnesota Vikings ✔ @Vikings
Today's #Vikings inactives
12:30 AM — 21 Nov 2016
50 50 Retweets 90 90 likes
View image on Twitter
View image on Twitter
Tampa Bay Buccaneers ✔ @TBBuccaneers
#Buccaneers Inactives#TBvsKC #SiegetheDay
12:30 AM — 21 Nov 2016
10 10 Retweets 17 17 likes
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View image on Twitter
New York Giants ✔ @Giants
#Giants Inactives: TE Larry Donnell, WR Tavarres King, DB Leon Hall, OG Justin Pugh, OL Brett Jones, DT Robert Thomas, QB Josh Johnson
12:30 AM — 21 Nov 2016
84 84 Retweets 170 170 likes
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View image on Twitter
Buffalo Bills PR ✔ @BuffaloBillsPR
Today's @buffalobills inactives for #BUFvsCIN:
12:29 AM — 21 Nov 2016
31 31 Retweets 25 25 likes
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View image on Twitter
Arizona Cardinals ✔ @AZCardinals
Inactives for #AZvsMIN.

12:31 AM — 21 Nov 2016
13 13 Retweets 34 34 likes
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View image on Twitter
Tennessee Titans ✔ @Titans
#Titans inactives: WR McBride, RB Fluellen, DB Riley, wholesale jerseys china G Tretola, TE Amaro, OLB Dodd, NT Woods #TENvsIND
12:31 AM — 21 Nov 2016
24 24 Retweets 34 34 likes
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View image on Twitter
Detroit Lions ✔ @Lions
#Lions inactives for #JAXvsDET:
12:30 AM — 21 Nov 2016
53 53 Retweets 60 60 likes
BJ Kissel ✔ @ChiefsReporter
#Chiefs inactives today:

WR — J. Maclin
QB — T. Bray
CB — M. Peters
RB — B. Sankey
LB — D. Nicolas
OL — M. Person
DL — J. Howard
12:32 AM — 21 Nov 2016
96 96 Retweets 121 121 likes
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View image on Twitter
Chicago Bears ✔ @ChicagoBears
Inactive #Bears for #CHIvsNYG.
12:34 AM — cheap jerseys china 21 Nov 2016
35 35 Retweets 48 48 likes
Cincinnati Bengals ✔ @Bengals
#Bengals inactives 11/20 #BUFvsCIN

-QB J. Driskel
-WR C. Core
-CB K. Russell
-LB R. Maualuga
-C. Westerman
-DT D. Williams
-TE C.J. Uzomah
12:34 AM — 21 Nov 2016
18 18 Retweets 31 31 likes
Indianapolis Colts ✔ @Colts
Colts Inactives:

25 Patrick Robinson
40 Christopher Milton
50 Deon King
62 Le'Raven Clark
63 Austin Blythe
81 Devin Street
92 Curt Maggitt
12:35 AM — 21 Nov 2016
43 43 Retweets 81 81 likes
Jacksonville Jaguars ✔ @Jaguars
Gameday update: Smith active, Skuta inactive
12:34 AM cheap nfl jerseys — 21 Nov 2016

Gameday update: Smith active, Skuta inactive
11 11 Retweets 6 6 likes
David Helman ✔ @HelmanDC
Cowboys inactives: Mark Sanchez, Morris Claiborne, Darius Jackson, Barry Church, Mark Nzeocha, Chaz Green, Benson Mayowa.
12:33 AM — 21 Nov 2016 · Arlington, TX
123 123 Retweets 257 257 likes
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Pittsburgh Steelers ✔ @steelers
12:38 AM — 21 Nov 2016
40 40 Retweets 142 142 likes
Today's #Lions inactives for #JAXvsDET:

DeAndre Levy
Tyrunn Walker
Joe Dahl
Cornelius Lucas
Adairius Barnes
Justin Forsett
Corey Fuller

— Detroit Lions (@Lions) November 20, 2016
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View image on Twitter
Miami Dolphins ✔ @MiamiDolphins
Today's inactives.
3:35 AM — 21 Nov 2016 · Los Angeles, CA
47 47 Retweets 85 85 likes
Myles Simmons ✔ @MylesASimmons
#RamsInactives: S Mannion, B Countess, T Hill, J Brown, P Murphy, T Hemingway, M Longacre
3:36 AM — 21 Nov 2016
4 4 Retweets 3 3 likes
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San Francisco 49ers ✔ @49ers
#49ers inactives for #NEvsSF

Kickoff 1:25pm on @NFLonCBS
3:56 AM — 21 Nov 2016
45 45 Retweets 72 72 likes
Philadelphia Eagles ✔ @Eagles
#Eagles inactives: S T. Brooks, CB Grymes, DE Means, OL Tobin, OL Andrews, OL Gordon, DT Hart
3:56 AM — 21 Nov 2016
67 67 Retweets 151 151 likes
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View image on Twitter
Seattle Seahawks ✔ @seahawksPR
Seahawks inactives vs. the Eagles
3:55 AM — 21 Nov 2016
75 75 Retweets 160 160 likes
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View image on Twitter
New England Patriots ✔ @Patriots
#Patriots inactives.#NEvsSF
3:55 AM — 21 Nov 2016
289 289 Retweets 529 529 likes
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View image on Twitter
Green Bay Packers ✔ @packers
Clay Matthews & Jared Cook are ACTIVE tonight for the #Packers.#GBvsWAS inactives list:
7:59 AM — 21 Nov 2016
228 228 Retweets 560 560 likes
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View image on Twitter
Washington Redskins ✔ @Redskins
#Redskins inactives for #GBvsWAS.
8:00 AM — 21 Nov 2016
47 47 Retweets cheap jerseys from china 74 74 likes
We’ll see if any of the players who are playing through injuries or if the absence of those that wound up inactive ultimately decides any games on Sunday. With the playoff race ramping up and stakes getting higher, you’d have to imagine that one injury could be the deciding factor in at least a couple of matchups.

Rapid assay to test anti-cancer drugs under physiological conditions

Medicilon offers fully integrated pharmaceutical services for the global scientific community. We focus on providing an exceptional client-centered experience and advancing the drug discovery process. Since the founding of our company in 2004, our integrated services across biology, chemistry and preclinical services are uniquely designed to help clients developing their research and discovery programs from the initial idea stage to the IND filing phase. Email:[email protected]
This invention relates to an assay that allows for the rapid determination of the activity of a given drug against leukemic cells either taken from a patient or derived from a cell line. The assay is performed in the presence of whole blood or serum.
The research leading to the present invention was supported, at least in part, by a grant from the National Institutes of Health (NIH R01DE16133). Accordingly, the Government may have certain rights in the invention.
This invention relates to an assay that allows for the rapid determination of the activity of a given drug against leukemic cells either taken from a patient or derived from a cell line.
Each year, more than 60,500 people die of hematologic malignancies (leukemia, lymphoma, myeloma) with more than 110,000 new annual diagnoses in the US alone. Current treatment for these cancers includes the use of synthetic compounds that target the cell division process of nearly all cells of the body, not just the cancerous ones. Furthermore, a significant percentage of patients eventually show resistance to many of the drugs, thus rendering treatment largely ineffective. Indeed, there is an effort to identify agents that induce cancer cell death by methods other than damage to DNA or cell division (20).
The initial identification and testing of novel anti-cancer agents relies on in vitro killing assays using relevant cancer cell lines. While in vitro assays performed under cell culture conditions prove useful and necessary for preclinical testing of new therapeutics, extrapolation to the physiological conditions of a living organism is often difficult or impossible (27). Because of the high cost of drug development ($800 million), new drug screens are constantly being sought to more efficiently eliminate or identify candidate therapeutic agents (27). Indeed, increasing the clinical success rate from ⅕ to ⅓ because of more effective preclinical drug screens would reduce drug development costs by more than $200 million (27).
The activity, specificity, or toxicity of a compound in the physiological environment can vary significantly from cell culture conditions. While no in vitro assay or screen can represent the complexity of the human body, several assays have been developed to more closely mimic in vivo conditions. Several of these assays include the colony forming cell assay using bone marrow cells (27,29), hepatic drug biotransformation assays (3), and assays in whole blood (4,45). Because most chemotherapeutic agents are administered intravenously and are therefore immediately affected by blood cell components, screening for potential drugs in the presence of whole blood would be expected to yield more meaningful results. Blood contains biological components, such as proteases, antibody, and blood cells, which can affect the nature of a compound. For example, red blood cells and plasma proteins are known to affect the pharmacokinetics of drugs such as the anti-cancer agents docetaxel and gemcitabine (8,9). Vaidyanathan et al. (43) also reported that the cardioprotective drug, dexrazoxane, inhibits binding of the anti-cancer agent, doxorubicin, to red blood cells and that this interaction alters the pharmacokinetics of doxorubicin, and Clarke et al. (4) used an in vitro whole blood assay to study the binding affinity of a surrogate anti-CD11a monoclonal antibody to blood components. In addition, leukocytes produce a cytochrome P450 isoform (CYP2E1) that is involved in drug biotransformation (3). Thus, identifying and studying drugs in the presence of whole blood or blood components can offer a unique advantage over assays using cells in monoculture.
For studies on leukemia therapeutics, the cell line HL-60 is used as a standard target cell line. HL-60 cells were originally isolated from a 36-year-old female patient with acute promyelocytic leukemia (13). Testing the efficacy of anti-leukemia therapeutics against HL-60 cells in whole blood or other biological material is currently a challenge due to the inefficiency in differentiating the viability of HL-60 cells from other cells. Thus there remains a need to develop an efficient screen for anti-leukemia therapeutics and facilitate preclinical studies on a highly specific bacterial leukotoxin as a novel anti-leukemia therapeutic agent.
Accordingly, a stable bioluminescent HL-60 cell line whose viability can be rapidly and effectively determined in the presence of whole blood and live animals has now been developed along with an assay that allows for the rapid determination of the activity of a given drug against a leukemic cells either taken from a patient or derived from a cell line. The assay is carried out in the presence of whole blood or serum. This quantitative assay can screen thousands of drugs at a time or multiple concentrations of a drug in a 96- or 384-well format.
Screens for compounds and proteins with anti-cancer activity employ viability assays using relevant cancer cell lines. For leukemia studies, the human leukemia cell line, HL-60, is often used as a model system. To facilitate the discovery and investigation of anti-leukemia therapeutics under physiological conditions, HL-60 cells have been engineered that stably express firefly luciferase and produce light. Bioluminescent HL-60luc cells could be rapidly detected in whole blood with a sensitivity of approximately 1000 viable cells. Treatment of HL-60luc cells with a bacterial leukocyte-specific toxin or the drug chlorambucil revealed that the bioluminescent viability assay is more sensitive than the trypan blue dye exclusion assay. HL-60luc cells administered intraperitoneally (i.p) or intravenously (i.v.) were visualized in living mice using an in vivo imaging system (IVIS). The rapidity and ease of detecting HL-60luc cells in biological fluid indicates that this cell line can be used in high throughput screens for the identification of drugs with anti-leukemia activity under physiological conditions.
In vivo bioluminescence imaging (BLI) is a technology that allows visualization of live bioluminescent cells (mammalian, bacterial, viruses) in complex biological material and living animals (24,31). Firefly luciferase has been used extensively in reporter systems and its expression can be measured quantitatively using a luminometer or highly sensitive charge coupled device (CCD) camera. Rocchetta et al. (32) found that the CCD camera was approximately 25 times more sensitive than a luminometer, and so the IVIS 50 imaging system (Xenogen, Alameda, Calif.) was used for the work presented here. Luciferase reacts with its substrate, luciferin, to produce oxyluciferin and light (11). Because ATP and oxygen are required for the reaction, photon production has been used as a quantitative measurement of cellular viability (14). Animal studies have demonstrated a strong correlation between the abundance of emitted photons and number of cells present in a given tissue or animal (5,11).
In general, the field of oncology has utilized BLI extensively to study the effects of anti-cancer therapy in vivo (15,23). However, application of BLI to study hematologic malignancies has been limited (6,22,44), and to date, there are no bioluminescent hematologic cell lines commercially available (Xenogen Corp., Alameda, Calif.). Validation of BLI in preclinical study models has been carried out using currently available methods and evidence indicates that BLI has excellent sensitivity and offers unique advantages (5,25,31,33). For example, non-invasive BLI allows visualization of cells temporally and spatially, thus permitting small changes in cell number and localization to be detected over time (24,31). In addition, animals need not be sacrificed at each sampling time point, decreasing the number of animals that are required for an experiment and minimizing inconsistency from animal-to-animal variations. A bioluminescent HL-60 cell line has been engineered that can be visualized in whole human blood and living mice and whose viability can be rapidly determined. A WBC-specific bacterial toxin has been shown to be active in blood. The engineered HL-60luc cells of the invention behave similar to the parental HL60 cell line. The BLI signal peaked approximately one hour following the addition of luciferin but remained relatively high for several hours. This type of in vitro kinetics where an early peak in luminescence is followed by a slow decline is consistent with other BLI cell lines. The detection limit of 1000 viable cells is also consistent with other reports (35,36). Because human blood contains plasma proteins, such as antibody and proteases, and other cells, that may affect the activity, availability, or stability of a drug, the anti-leukemia assays with HL-60luc cells in the presence of blood can yield more physiological results than with buffer or growth media alone.
There is a significant difference between the sensitivity of BLI and the trypan blue dye. exclusion assay. For a cell to be detected as nonviable with the trypan blue assay, the dye must enter the cytoplasm of the cell. Trypan blue is a relatively large molecule (mw 960.8) and while many cells may be metabolically dead, their membranes could be sufficiently intact to exclude the dye to appear viable. In contrast, BLI detects killing sooner because ATP is no longer available in a metabolically dead cell. The results are in strong agreement with Kuzmits et al. (17) who found that an ATP/bioluminescent assay with HL-60 cells indicated nearly complete killing after a 24 hour incubation with 5.7 μmol/l doxorubicin, while the trypan blue assay indicated almost no killing after 48 hours with the same drug concentration. Furthermore, Petty et al. (30) reported that a bioluminescent ATP assay could detect as few as 1500 viable cells/well while the MTT assay could not detect less than 25,000 cells/well.

Method for breeding experimental macaca mulatta

Medicilon offers fully integrated pharmaceutical services for the global scientific community. We focus on providing an exceptional client-centered experience and advancing the drug discovery process.Since the founding of our company in 2004, our integrated services across biology, chemistry and preclinical services are uniquely designed to help clients developing their research and discovery programs from the initial idea stage to the IND filing phase. Email:[email protected]
The invention provides a method for breeding experimental macaca mulatta. The mode of female money single-cage raising and regular mating is adopted in the mating period, the mode that infant monkeys and a female monkey are raised in a concentrated mode in the lactation period and an adult male monkey is isolated is adopted, the monkey group fighting problem is effectively solved, the infant monkeys are raised in a single-breeding monkey cage in the ablactation period, the breeding quality is further improved, and the health condition of the macaca mulatta can be discovered and managed in time. The breeding rate and the pregnancy rate of the macaca mulatta are further improved, the phenomenon that the female monkey of the right age is infertile in the breeding period is greatly reduced, the oestrus, mating and farrowing activities of personal macaca mulatta can be observed conveniently, and the health condition of the macaca mulatta can be discovered and managed in time. According to the method, overall comprehensive breeding management is combined with rich and reasonable breeding equipment, and thus the yield and the quality of the experimental macaca mulatta are greatly improved.
said the monkey (Macaca mulatta) belong Primates (Primates) Cercopithecidae (Eereopithecidae) called Monkey (Macaca) animals, as «Endangered Species of Wild Fauna and Flora International Trade Convention (CITES)» Appendix II species.
macaque as human kinship with the closest species of non-human primates (Nonhuman Primates, NHP) and human genetic material more than 95% homology, and the organizational structure, immunity, physiology and metabolism respect human height approximation, which has a clear comparative advantage in biomedical research traitor, a traitor and basic research has become an ideal animal model to solve problems of human health and disease in pre-clinical research traitor. China SFDA and FDA clearly requires more than two types of new drugs in clinical trials before, must obtain reliable data on NHP animal experiments. China also states: «The neurological, psychiatric, anesthesia type, biological products category, appliances and other family planning medicines must be approved by NHP animal experiments approved before entering clinical trials.» At present, with AIDS, Parkinson's, cancer establish lung damage, liver damage and other long-standing human ills NHP disease models, as well as related drugs especially preclinical study based evaluation, NHP application is not around the past Hom. NHP proteins in particular the importance of new drugs biological products for drug development is evident.
monkeys, as the Chinese national animal protection, population traitor applied research in experimental animals has been increasing year by year in recent years, but mainly due to the current international breeding cynomolgus monkeys mainly just for monkeys reared in infancy, mainly from the wild, wild monkey experiment with one hand because there is no clear genetic background, a clear and stable microbial biological characteristics of the state, so the reliability of the experimental results is doubtful; the other hand, wild monkeys to capture inevitably result in excessive depletion of wildlife resources, and the development of human civilization very inconsistent.
The experimental primates China attaches great importance to the same resource, macaque experiments included in the «national» five «animals platform construction» project to provide support conditions for the development of national strategic emerging industries. Ministry formulated the «primate laboratory animal husbandry management practices and quality standards», set up a «primate laboratory animal industry strategic alliance.» It is because of the great value of the experimental monkeys, Western countries (including the country) will be listed as a strategic resource research. Some experts even predict that the future of competition in the pharmaceutical industry may be competitive experiments in primates resources.
Thus genetic differences to understand the genetic background of experimental monkeys and populations through existing genetic records management system to adjust the macaque experiments, genetic information management, the establishment of experimental animals macaque detailed individual files and pedigree systems, establish an effective, accurate and reliable, quick and easy monitoring of genetic background, while establishing a sound feeding, breeding standard operating procedures, epidemic prevention system and disease prevention and control program for the cultivation of macaque experimental populations to provide technical support is particularly important.
According to 2009 statistics, the breeding stock of 21 million Chinese monkeys, of which nearly 30,000 macaques. According to 2011 statistics, nearly a decade of international market demand for the experimental monkeys annual growth rate of over 20%. In 2010, global demand macaque experiment nearly 200,000, while the amount of global experimental macaque breeding year only 13 million only, the market demand gap is very obvious. According to the relevant forecast shows the next five years (2012-2016), the global market for medical experiments macaque demand will maintain strong growth momentum in 2016 demand will reach 25-30 million.
For the purposes of China's domestic demand, along with increasing levels of Chinese science and technology, and the comparative advantages of various costs, large international pharmaceutical companies and research institutions have the R & D center traitor into China, or the relevant R & D tasks Outsourcing. This is certainly experimental animals for China, but also certainly to the global development of animal experiments. Will effectively promote domestic monkeys and usage patterns of animals, in the foreseeable time frame will be a rising trend.
It has been reported worldwide each year for research Macaca animals only up to 10 million, China needs thousands every year. Although some countries have invested heavily in the establishment of a number of monkeys games, but still need to produce importers from China and Vietnam, a lot of rhesus macaques.
keeping the size and needs of Chinese monkeys gradually expanded, but because of long-term lack of standardized management, leading to disorderly competition between industries, violations of law, underdevelopment and low quality animal series of problems, not only cause for conservation a huge risk, but also damaged China's international reputation.

10 Best NFL Thanksgiving Day Games of All-Time

There have been hundreds of NFL Thanksgiving games played, but here are the 10 best contests to take place on Turkey Day.

The NFL on Thanksgiving Day is one of the best traditions in sports. What wholesale jerseys sports fan doesn’t have fond memories of gathering around the TV with their family and watching the Dallas Cowboys and Detroit Lions play on the holiday?

However, fond memories don’t always translate into high-quality football games. Just look at one year ago when the Dallas Cowboys got absolutely trounced by the Carolina Panthers right out of the gate. So in the spirit of the holiday, let’s be thankful for the great matchups that we’ve seen throughout the years. To do that, we’ll look at the 10 best NFL games on Thanksgiving in history.

Before we get to cheap jerseys china the top 10, let’s take a quick peek at some honorable mentions that almost cracked the list.

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Dallas Cowboys 24, cheap nfl jerseys San Francisco 49ers 24 — November 27th, 1969

The 2-7-1 49ers went up early on the 8-2 Cowboys by a couple scores then survived an onslaught to earn the tie. This was five seasons before overtime was implemented and way before two-point conversions. Dallas finished 11-2-1 and had to host the Browns in the playoffs.

New York Titans 46, Denver Broncos 45 — cheap jerseys from china November 22nd, 1962

A year to the day before JFK was assassinated, the New York Titans took a big 24-7 lead, lost the lead in the fourth, trailed by 10, and came back for a one-point win. Titans quarterback Johnny Green threw five touchdowns.

Baltimore wholesale jerseys china Ravens 22, Pittsburgh Steelers 20 — November 27th, 2013

The Ravens were up 19-7 at the beginning of the fourth quarter before Ben Roethlisberger and company stormed back. Pittsburgh was one failed two-point conversion from tying the game. You might remember this as the game in which Steelers head coach Mike Tomlin tried to trip Baltimore returner Jacoby Jones as he ran down the sideline.

Detroit Lions 44, Minnesota Vikings 38 — November 23rd, 1995

Scott Mitchell and Warren Moon combined to throw for almost 750 passing yards and seven touchdowns. Three different Lions receivers had more than 100 yards. Moon drove the Vikes to the Detroit 38 before throwing the game-ending interception.

Now onto the main event, the top 10 games on NFL Thanksgiving of all-time.

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Best NFL Roster Made Up of Fictional Players

If you cheap jerseys from china made an NFL roster of fictional characters from football movies throughout the years, what would it look like?

Football movies are almost always instant classics for the die-hard fans. Yeah, there may have been wholesale jerseys china some bad ones over the years, but we have been blessed with some unbelievable movies featuring the gridiron in our lifetime.

Movies about football, in particular, have been some of the best movies of our time. When you cheap nfl jerseys look back on movies like Varsity Blues, Jerry Maguire, Any Given Sunday, Remember The Titans, Friday Night Lights, and The Replacements (just to name a few of my favorites) you see that we’ve been lucky to have such great movies to watch.

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If you are like me, when you watch those movies, you wonder what it would be like if cheap jerseys any of the movie characters were real. You think about their dominant play throughout the movie and just try to picture them playing in the NFL.

So, what would it be like if those fictional players were in the NFL? Which players would make a final 53-man roster and make an impact in the NFL? I have composed (what I believe to be) the best NFL roster of these fictional characters. The roster is just the starting 22-man unit in addition to a kicker, punter, return man, and head coach. And you’ll certainly be wanting to watch these fictional player in action afterwards to see if you agree that they could cut it in the NFL.

Note: Any videos featured in throughout this post may contain NSFW wholesale jerseys language.

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